Blar i forfatter "Akhtar, Muhammad Asad"

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    • “EFFECT OF IRRADIATION ON THE IMMUNOREGULATORY FUNCTIONS EXERTED BY TUMOUR FIBROBLASTS ON MACROPHAGES” 

      Akhtar, Muhammad Asad (Master thesis; Mastergradsoppgave, 2018-11-19)
      Summary Background/aim of the study: Carcinoma-associated fibroblasts (CAFs) represents a heterogeneous population of cells and are considered one of the dominant stromal component of solid tumours, performing a crucial role in tumour proliferation and metastasis. The main objective of this study was to investigate the immunoregulatory features of CAFs isolated from non-small cell lung carcinomas ...

    • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

      Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
      The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...